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KMID : 0545119960060040245
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Journal of Microbiology and Biotechnology
1996 Volume.6 No. 4 p.245 ~ p.249
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Structure Determination and Biological Activities of Elaiophylin Produced by Streptomyces sp. MCY-846
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LEE, SANG-YONG
KIM, MI-SOON/KIM, HANG-SUB/KIM, YOUNG-HO/HONG, SOON-DUCK/LEE, JUNG-JOON
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Abstract
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A cytotoxic compound, 846I was isolated from the culture of Streptomyces sp. strain MCY846 by its cytotoxicity against gastric cancer cell line SUN-1. The IR, UV and NMR spectra of 846I were identical to those of elaiophylin. This compound showed moderate cytotoxicity against several cell lines and exerted strong inhibitory effect on the synthesis of nitric oxide in the lipopolysaccharide stimulated-Raw 264.7 cells.
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